Effect of diet on the gut microbiome

Diet has a significant impact on Intestinal microbiome (intestinal flora), Not only does it play an important role in what and how much is eaten, but the timing of food intake is also essential.

In a new study involving experts University of California-San Diego studied the effects of diet and meal timing on the composition of the gut microbiome and RNA molecules (transcriptomes) produced in cells in rats. The results were published in the journal “cell report“Published.

trillions of microorganisms in the gut

Estimated to live in the intestines of humans 500 to 1,000 types of bacteria and total approx 100,000 trillion microorganisms, researchers report. Using mouse models, they have now investigated how diet and feeding patterns affect these gut microbes.

In addition, the effect of changes in the gut microbiome for the health of animals, especially obesity and type 2 diabetes,

What happens in the ileum and cecum?

in rats and humans, the so-called ileum Represents the last part of the small intestine. This segment is attached to the cecum, which is the first part of the large intestine.

in ileum Nutrients extracted from liquefied food and in the so-called cecum, which marks the beginning of the large intestine, begins freeze dryingTeam explains.

Both processes are extremely complex, dynamic and highly influenced by many factors. These types range from and meal time that up Microbial Composition in the Gut,

affects the intestinal microbiome, among other things digestionThe Nutrient intakeThe Vitamin synthesis And this development of the immune system,

Changes in the Gut Microbiome During the Day

“It is important to recognize that the gut microbiome is constantly changing, not only based on what we eat, but also based on the time of day.‘ explains the study authors Dr. Amir Zarinpari one in Press release,

Weaknesses of previous research

Experts further report that most of the research to date has found only one snapshot Evaluated in this constantly changing environment. This makes it difficult to understand what is actually going on in the gut.

The current study uses against Multiple snapshots spread across the dayTo better analyze how food and the microbiome interact to influence body weight and diabetes.

The team paid special attention to how diet-related obesity and a time-limited diet composed of Ileal microbiome and transcriptome influence.

Weight gain due to disrupted gut microbiome

Diet-induced obesity and time-restricted food deficits found to be increased in mouse models Disorders of Gut Microbiome Rhythms led. In addition, important signaling pathways were also disrupted, resulting in The animals became fat and their health deteriorated,

temporarily limited food intake

Access to food has a time limit, according to study author Dr. Ana Carolina Dantas Machado Clearly positive effects on the composition and impaired signaling pathways of the intestinal microbiome of animals.

The study highlights the importance of diet and time-limited eating patterns in maintaining a healthy gut microbiome, which in turn regulates the circadian rhythms (called the body clock) that govern metabolic health.

Cyclic changes in the gut microbiome According to the research team, support circadian rhythms and thus . support the regulation and control of Glucose, Cholesterol and Fatty AcidsWhich has a positive effect on overall metabolic health.

,It is a very complex relationship between the microbiome and the host, with the microbiome co-determining the host’s gastrointestinal function and health.“, To analyse Dr. Amir Zarinpari, (as)