Irritable bowel syndrome caused by histamine-producing intestinal bacteria

through the production of histamine can make sure gut bacteria to dilapidate Abdominal pain And a sensitive gut disease to lead. A low fermentable carbohydrate diet and medications directed against the bacterial histamine may serve as therapy here.

a research team from McMaster University And this Queen’s University is a bacterium “histamine superproducer” Discovered in the Gut, Too chronic abdominal pain And this sensitive gut disease Can lead. The results of the related study were published in the specialist journal “science translation medicine” free.

Gut flora affects health

intestinal flora Associated with wide-ranging health effects, extend well beyond the digestive system. For example, recent studies have shown that Intestinal flora effect on the development of rheumatic diseases is and about The gut-brain axis that affects the brain and behavior,

In the digestive system, the health effects of gut microbiota However, clearly visible. So the intestinal flora was already chronic abdominal pain And this sensitive gut disease has been implicated, but the specific pathophysiological mechanisms remain unclear.

Discover pathophysiological mechanisms

In the current study, researchers are trying to understand this. To do this, they first examined stool samples from Canadian and American patient cohorts.

“We followed these patients for several months and found higher fecal histamine levels when the patients reported severe pain and lower histamine levels when pain-free”Study lead author explains Professor Premisl Bursico Of McMaster University,

Klebsiella aerogenes major histamine producer

In experiments performed on mice, the research team was then able to identify the bacterium Klebsiella erogenes as the most important histamine producer Identify. According to the researchers, bacteria can convert dietary histidine, an essential amino acid found in animal and vegetable proteins, into histamine.

According to the researchers, the bacterial strain was also present in the faecal microbiota of three independent patient groups with irritable bowel syndrome compared to healthy individuals. Often represent.

It has also become clear in the experiments that bacterial histamine through the immune system of the intestine histamine 4 receptor Activate, which pulls immunological mast cells into the gut. more histamine and other pain mediators are produced by mast cells, what swelling and pain The reason, the team explains.

low fermentable carbohydrate diet

were the rats using the diet low fermentable carbohydrates When fed, a reduction in so-called visceral hypersensitivity and accumulation of mast cells in the large intestine could be detected.

Even in patients with irritable bowel syndrome, reducing fermentable carbohydrate intake is associated with stomach pain reliefwhich was associated with changes in the intestinal flora and lower histamine concentrations in the urine.

new therapeutic options

In a study done on rats medicinal blockade The histamine-4 receptor also inhibits so-called visceral hypersensitivity and reduces the accumulation of mast cells in the large intestine.

it indicates that therapeutic strategiesWhich targets the bacterial histamine, may help treat many people with irritable bowel syndrome and chronic abdominal pain.

“Now that we know how histamine is produced in the gut, we can identify and develop therapies that target histamine-producing bacteria.”Summarizes the first author giada de palma Of McMaster University,

“Although the treatment of mast cells in irritable bowel syndrome has been explored, a novel approach based on our research would be to target the bacterial histamine production, or H4R pathway.”couple Professor Bursico,

by a Blocking H4 Receptors The recruitment of mast cells to the colon and thus the development of prevents stomach ache Hope to be co-author Professor Stephen Vanner Of Queen’s University, (FP)