The DGN now stresses that anyone who has had chickenpox in the past can, in theory, get herpes zoster. Health data from the US OLDW database (“Optum Labs Data Warehouse”) of 2,039,854 people vaccinated against SARS-CoV-2 have now been analysed, in a large retrospective cohort study published on November 16 by the University of California, San Francisco ( BioNTech/Pfizer, Moderna or Johnson-Johnson, in the period 12/2020 – 6/2021). The mean age of those vaccinated was 43.2 ± 16.3 years, 50.6 percent were female. Finally, from the entire cohort, 1,451 people with a herpes zoster diagnosis were examined for frequency of herpes zoster diagnosis in the “exposure interval” (30 days after the first or second vaccination dose). The results were compared at subsequent intervals (“control interval” 30–60 days after vaccination). “Consequently, COVID vaccination was not associated with an increased risk of VZV reactivation (incidence rate ratio IRR 0.91; p = 0.08)”, explains DGN. And that, although according to the study’s authors, is definitely a praiseworthy system will exist by which mRNA-based COVID-19 vaccines can cause herpes zoster infection. Accordingly, mRNA vaccines stimulate toll-like receptor signaling pathwayWhich is involved in latency and reactivation of varicella-zoster virus.